Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

During nervous system development, an extracellular matrix (ECM) plays a pivotal role
through surface topography and microenvironment signals in neurons and neurites …

Topography, among other physical factors such as substrate stiffness and extracellular
forces, is known to have a great influence on cell behaviours. Optimization of topographical …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Cell–material interactions constitute a key fundamental topic in biomaterials study. Various
cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials …

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial
and mechanical cues to which cells respond. In addition to soluble chemical factors …

Efficacy of aligned poly (l-lactic acid)(PLLA) nano/micro fibrous scaffolds for neural tissue
engineering is described and their performance with random PLLA scaffolds is compared as …

Topographical cues, independent of biochemistry, generated by the extracellular matrix may
have significant effects upon cellular behavior. Studies have documented that substratum …

In the body, cells encounter a complex milieu of signals, including topographical cues, in the
form of the physical features of their surrounding environment. Imposed topography can …

Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …