Human embryonic stem cells

MF Pera, B Reubinoff, A Trounson - Journal of cell science, 2000 - journals.biologists.com
Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated
indefinitely in the primitive undifferentiated state while remaining pluripotent; they share …

Role of oxidative stress in stem, cancer, and cancer stem cells

AA Dayem, HY Choi, JH Kim, SG Cho - Cancers, 2010 - mdpi.com
The term ''oxidative stress” refers to a cell's state characterized by excessive production of
reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory …

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

SC Zhang, M Wernig, ID Duncan, O Brüstle… - Nature …, 2001 - nature.com
The remarkable developmental potential and replicative capacity of human embryonic stem
(ES) cells promise an almost unlimited supply of specific cell types for transplantation …

Matrix cells from Wharton's jelly form neurons and glia

KE Mitchell, ML Weiss, BM Mitchell, P Martin… - Stem …, 2003 - academic.oup.com
We have identified an easily attainable source of primitive, potentially multipotent stem cells
from Wharton's jelly, the matrix of umbilical cord. Wharton's jelly cells have been propagated …

Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

H Fong, KA Hohenstein, PJ Donovan - Stem cells, 2008 - academic.oup.com
Human embryonic stem (hES) cells, derived from blastocysts, are capable of unlimited self-
renewal and differentiation into all cell lineages of the body. Because of their pluripotent …

[HTML][HTML] WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells

J Hao, TG Li, X Qi, DF Zhao, GQ Zhao - Developmental biology, 2006 - Elsevier
Embryonic stem (ES) cells rely on growth factors provided by feeder cells or exogenously to
maintain their pluripotency. In order to identify such factors, we have established sub-lines of …

Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation

M Kuwana, Y Okazaki, H Kodama… - Journal of Leucocyte …, 2003 - academic.oup.com
Circulating CD14+ monocytes are precursors of phagocytes, such as macrophages and
dendritic cells. Here we report primitive cells with a fibroblast-like morphology derived from …

Stem cells: hype and reality

CM Verfaillie, MF Pera… - ASH Education Program …, 2002 - ashpublications.org
This update discusses what is known regarding embryonic and adult tissue-derived
pluripotent stem cells, including the mechanisms underlying self-renewal without …

Neurotrophins mediate human embryonic stem cell survival

AD Pyle, LF Lock, PJ Donovan - Nature biotechnology, 2006 - nature.com
Growth of human embryonic stem (hES) cells as a pluripotent population requires a balance
between survival, proliferation and self-renewal signals. Here we demonstrate that hES cells …

[HTML][HTML] Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells

M Rao - Developmental biology, 2004 - Elsevier
The past few years have seen remarkable progress in our understanding of embryonic stem
cell (ES cell) biology. The necessity of examining human ES cells in culture, coupled with …