Glucosylglycerate metabolism, bioversatility and mycobacterial survival
Despite the progressive decline in tuberculosis mortality, strains resistant to our dated
antibiotics remain a global threat, as are the emerging nontuberculous mycobacteria …
antibiotics remain a global threat, as are the emerging nontuberculous mycobacteria …
Pathogenic Nocardia cyriacigeorgica and Nocardia nova evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways
Nocardia spp. are Gram-positive opportunistic pathogens that affect largely
immunocompromised patients, leading to serious pulmonary or systemic infections …
immunocompromised patients, leading to serious pulmonary or systemic infections …
Quick-soaking of crystals reveals unprecedented insights into the catalytic mechanism of glycosyltransferases
Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from nucleotide-sugar or
lipid-phospho-sugar donors to a wide range of acceptor substrates, generating a remarkable …
lipid-phospho-sugar donors to a wide range of acceptor substrates, generating a remarkable …
Structural snapshots and loop dynamics along the catalytic cycle of glycosyltransferase GpgS
D Albesa-Jové, J Romero-García, E Sancho-Vaello… - Structure, 2017 - cell.com
Glycosyltransferases (GTs) play a central role in nature. They catalyze the transfer of a sugar
moiety to a broad range of acceptor substrates. GTs are highly selective enzymes, allowing …
moiety to a broad range of acceptor substrates. GTs are highly selective enzymes, allowing …
Distinct functional properties of secretory l-asparaginase Rv1538c involved in phagosomal survival of Mycobacterium tuberculosis
The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) stains has escalated the
need for developing more efficient drugs and therapeutic strategies against tuberculosis …
need for developing more efficient drugs and therapeutic strategies against tuberculosis …
A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures
Mycobacterium hassiacum is so far the most thermophilic among mycobacteria as it grows
optimally at 50° C and up to 65° C in a glycerol-based medium, as verified in this study …
optimally at 50° C and up to 65° C in a glycerol-based medium, as verified in this study …
Development of an ESI-LC-MS-Based Assay for Kinetic Evaluation of Mycobacterium tuberculosis Shikimate Kinase Activity and Inhibition
A simple and reliable liquid chromatography–mass spectrometry (LC-MS) assay has been
developed and validated for the kinetic characterization and evaluation of inhibitors of …
developed and validated for the kinetic characterization and evaluation of inhibitors of …
An investigation into an unusual glycan branching enzyme from Mycobacterium tuberculosis
JS Gusthart - 2018 - eprints.soton.ac.uk
Mycobacterium tuberculosis (Mtb), the pathogen that causes tuberculosis (TB), is showing
increasing resistance to current drug therapies. It is therefore essential that novel drug …
increasing resistance to current drug therapies. It is therefore essential that novel drug …
Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stress
CIS Martins - 2016 - estudogeral.uc.pt
Os antibióticos tiveram uma enorme relevância na modernização da medicina, sendo hoje
difícil imaginar a prática da medicina sem eles. Contudo, a resistência a estes compostos …
difícil imaginar a prática da medicina sem eles. Contudo, a resistência a estes compostos …
[图书][B] Application of hydrogen deuterium exchange mass spectrometry in protein-ligand and protein-protein interactions
S Guan - 2016 - search.proquest.com
Proteins are not static objects. They have a great variety of internal motions with different
amplitudes and different timescales. These internal motions play an important role in …
amplitudes and different timescales. These internal motions play an important role in …