The principles of directed cell migration
S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …
these cues induce directed cell migration towards or away from these signals. How cells …
Learning dynamical models of single and collective cell migration: a review
D Brückner, CP Broedersz - Reports on Progress in Physics, 2024 - iopscience.iop.org
Single and collective cell migration are fundamental processes critical for physiological
phenomena ranging from embryonic development and immune response to wound healing …
phenomena ranging from embryonic development and immune response to wound healing …
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration
During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …
components self-organize to generate localized protrusions. Although biochemical and …
Stiffness-dependent active wetting enables optimal collective cell durotaxis
The directed migration of cellular clusters enables morphogenesis, wound healing and
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …
Membrane ruffling is a mechanosensor of extracellular fluid viscosity
Throughout the body, cells are immersed in extracellular fluids (ECFs) that are typically
orders of magnitude more viscous than water or culture medium. Changes in the viscosity of …
orders of magnitude more viscous than water or culture medium. Changes in the viscosity of …
Emergent seesaw oscillations during cellular directional decision-making
Motile cells inside living tissues often encounter junctions, where their path branches into
several alternative directions of migration. We present a theoretical model of cellular …
several alternative directions of migration. We present a theoretical model of cellular …
A Scribble/Cdep/Rac pathway controls follower-cell crawling and cluster cohesion during collective border-cell migration
Collective cell movements drive normal development and metastasis. Drosophila border
cells move as a cluster of 6–10 cells, where the role of the Rac GTPase in migration was first …
cells move as a cluster of 6–10 cells, where the role of the Rac GTPase in migration was first …
Constriction imposed by basement membrane regulates developmental cell migration
E Molina López, A Kabanova, A Winkel, K Franze… - Plos …, 2023 - journals.plos.org
The basement membrane (BM) is a specialized extracellular matrix (ECM), which underlies
or encases developing tissues. Mechanical properties of encasing BMs have been shown to …
or encases developing tissues. Mechanical properties of encasing BMs have been shown to …
[HTML][HTML] Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo
L Penfield, DJ Montell - The Journal of Cell Biology, 2023 - ncbi.nlm.nih.gov
Cells migrate collectively through confined environments during development and cancer
metastasis. The nucleus, a stiff organelle, impedes single cells from squeezing into narrow …
metastasis. The nucleus, a stiff organelle, impedes single cells from squeezing into narrow …
Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration
A key regulator of collective cell migrations, which drive development and cancer
metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is …
metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is …