Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …

An obstacle in the treatment of human diseases such as cancer is the inability to selectively
and effectively target historically undruggable targets such as transcription factors. Here, we …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

Background The microRNA-200 family participates in the maintenance of an epithelial
phenotype and loss of its expression can result in epithelial to mesenchymal transition …

Purpose: Three genes, namely DNA methyltransferase (DNMT) 1, DNMT3A, and DNMT3B,
coding for DNMTs that affect promoter methylation status are thought to play an important …

The nucleotide 5-methylcytosine is involved in processes crucial in mammalian
development, such as X-chromosome inactivation and gene imprinting 1, 2, 3, 4, 5. In …

Although millions of cells are shed from a tumour every day, haematogenous metastasis is
believed to be very inefficient. This inefficiency is widely assumed to be a result of the …