Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …

Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's
disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors …

Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of
origin and in terms of function. Mitochondria and peroxisomes can also be turned over by …

Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuronal loss. The exact pathogenesis of PD is complex and …

Parkinson's disease (PD) is a major and progressive neurodegenerative disorder, yet the
biological mechanisms involved in its aetiology are poorly understood. Evidence links this …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …

Abstract Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene have been identified
as one of the most common genetic causes of Parkinson's disease (PD). The LRRK2 PD …

Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy
coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a …