Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over
40 years. Amentoflavone has been extensively recorded as a molecule which displays …

Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …

A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …

The potential of papain-like cysteine proteases, such as cathepsin B, as drug discovery
targets for systemic human diseases has prevailed over the past years. The development of …

A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-
like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma …

Over 110 years after the first formal description of Chagas disease, the trypanocidal drugs
thus far available have limited efficacy and several side effects. This encourages the search …

A simple, mild, straightforward, efficient and eco-friendly protocol has been developed for
the synthesis of a series of α-aminonitriles via the one-pot three-component Strecker …

Chagas disease affects millions of people in Latin America. This disease is caused by the
protozoan parasite Trypanossoma cruzi. The cysteine protease cruzain is a key enzyme for …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi, with approximately 6–7 million people infected worldwide, becoming a …

Abstract Chagas disease and Human African trypanosomiasis (HAT) are important public
health issues in Latin American and sub-Saharan African countries, respectively, and are …