International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

J Hillengass, S Usmani, SV Rajkumar… - The lancet …, 2019 - thelancet.com
Recent advances in the treatment of multiple myeloma have increased the need for accurate
diagnosis of the disease. The detection of bone and bone marrow lesions is crucial in the …

Single-cell profiling of tumour evolution in multiple myeloma—opportunities for precision medicine

AK Dutta, JB Alberge, R Sklavenitis-Pistofidis… - Nature Reviews …, 2022 - nature.com
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management

SV Rajkumar - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Multiple myeloma accounts for approximately 10% of
hematologic malignancies. Diagnosis The diagnosis requires≥ 10% clonal bone marrow …

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

AL Young, GA Challen, BM Birmann… - Nature communications, 2016 - nature.com
Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age
and predisposes individuals to haematological malignancy. Recent studies, utilizing next …

International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

SV Rajkumar, MA Dimopoulos, A Palumbo… - The lancet …, 2014 - thelancet.com
Summary This International Myeloma Working Group consensus updates the disease
definition of multiple myeloma to include validated biomarkers in addition to existing …

Genomic complexity of multiple myeloma and its clinical implications

S Manier, KZ Salem, J Park, DA Landau… - Nature reviews Clinical …, 2017 - nature.com
Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …

Multiple myeloma: diagnosis and treatment

SV Rajkumar, S Kumar - Mayo Clinic Proceedings, 2016 - Elsevier
The diagnosis and treatment of multiple myeloma has changed dramatically in the past
decade. The disease definition has been updated to include highly specific biomarkers in …

Multiple myeloma: 2016 update on diagnosis, risk‐stratification, and management

SV Rajkumar - American journal of hematology, 2016 - Wiley Online Library
Multiple myeloma accounts for approximately 10% of hematologic malignancies. The
diagnosis requires≥ 10% clonal bone marrow plasma cells or a biopsy proven …

Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

O Zavidij, NJ Haradhvala, TH Mouhieddine… - Nature cancer, 2020 - nature.com
Precursor states of multiple myeloma (MM) and its native tumor microenvironment need in-
depth molecular characterization to better stratify and treat patients at risk. Using single-cell …

Multiple myeloma: Available therapies and causes of drug resistance

V Pinto, R Bergantim, HR Caires, H Seca… - Cancers, 2020 - mdpi.com
Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM
include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors …