Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70
years. It is recommended by all relevant guidelines as a first-line treatment for maintenance …

Attention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous
neurodevelopmental condition for which curative treatments are lacking. Whilst …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

The objective of this study is to assess the global, regional, and national burden of bipolar
disorder (BPD) from 1990 to 2017, by gender, age, and social-demographic index (SDI) from …

Objective Widespread functional and structural alterations in the brain have been
extensively reported in unaffected relatives (RELs) of patients with bipolar disorder (BD) who …

Background Early-onset bipolar disorder (BD) is a complex psychiatric illness characterized
by mood swings, irritability and functional impairments. To improve our understanding of the …

There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies
observed in youth bipolar disorder (BD). This study examined the association of a polygenic …

Evidence suggests that adjunctive psychosocial intervention for the treatment of pediatric
bipolar spectrum disorders (BPSDs) is effective, feasible, and highly accepted as both an …

Background Pediatric bipolar disorder (PBD) is a severe disorder characterized by mood
fluctuations starting at a young age. Several neuroimaging studies revealed a specific …