Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein
involved in several post-transcriptional regulatory events of gene expression. Initially …

The general natures of protein dynamics and thermodynamics are analyzed on the basis of
irreversible theory for protein folding and protein thermodynamic structure theory. Main …

Alternative splicing contributes largely to cell differentiation and functional specification. We
previously reported that the RNA-binding protein RBM4 antagonizes the activity of splicing …

The international Human Proteome Project (HPP), a logical continuation of the Human
Genome Project, was launched on 23 September 2010 in Sydney, Australia. In accordance …

Alternative splicing (AS) of RNA is a key mechanism for diversification of the eukaryotic
proteome. In this process, different mRNA transcripts can be produced through altered …

Purpose.: To shed light on the pathogenicity of the mutations in the retinitis pigmentosa gene
CERKL, the authors aimed to characterize its transcriptional repertoire and focused on the …

An overview is presented on the status of studies on multiple codes in genetic sequences.
Indirectly, the existence of multiple codes is recognized in the form of several rediscoveries …

In this report, we studied the effect of RNA structures on the activity of exonic splicing
enhancers on the SMN1 minigene model by engineering known ESEs into different …

If we define a genetic code as a widespread DNA sequence pattern that carries a message
with an impact on biology, then there are multiple genetic codes. Sequences involved in …