Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Proton-coupled monocarboxylate transporters MCT1-4 catalyze the transmembrane
movement of metabolically essential monocarboxylates and have been targeted for cancer …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of
lactic acid from glucose/glutamine represents one of the consequences of such metabolic …

Lactate is an end product of glycolysis. As a critical energy source for mitochondrial
respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule …