[HTML][HTML] Diversity and versatility of p38 kinase signalling in health and disease
B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …
coordinated manner is key for survival and involves various signalling networks. Over the …
[HTML][HTML] Alternative splicing of MAPKs in the regulation of signaling specificity
The mitogen-activated protein kinase (MAPK) cascades transmit signals from extracellular
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …
[HTML][HTML] Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …
Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities
C Naro, P Bielli, C Sette - The FEBS Journal, 2021 - Wiley Online Library
Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐
processing, which ensure proper gene expression and diversification of human …
processing, which ensure proper gene expression and diversification of human …
[HTML][HTML] The SWI/SNF subunit BRG1 affects alternative splicing by changing RNA binding factor interactions with nascent RNA
A Gañez-Zapater, SD Mackowiak, Y Guo… - Molecular Genetics and …, 2022 - Springer
BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling
complexes mainly associated with transcriptional initiation. They also have a role in …
complexes mainly associated with transcriptional initiation. They also have a role in …
[PDF][PDF] Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
A Ulsamer, A Martínez-Limón, S Bader… - Cell Reports, 2022 - cell.com
Stress-activated protein kinases (SAPKs) enhance survival in response to environmental
changes. In yeast, the Hog1 SAPK and Mrc1, a protein required for DNA replication, define a …
changes. In yeast, the Hog1 SAPK and Mrc1, a protein required for DNA replication, define a …
[HTML][HTML] p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes
AA Dumont, L Dumont, J Berthiaume… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal
heart function. However, p38 also contributes to heart failure pathogenesis by affecting …
heart function. However, p38 also contributes to heart failure pathogenesis by affecting …
[HTML][HTML] Regulation of phosphosignaling pathways involved in transcription of cell cycle target genes by TRH receptor activation in GH1 cells
Z Drastichova, R Trubacova, J Novotny - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Thyrotropin-releasing hormone (TRH) is known to activate several cellular signaling
pathway, but the activation of the TRH receptor (TRH-R) has not been reported to regulate …
pathway, but the activation of the TRH receptor (TRH-R) has not been reported to regulate …
[HTML][HTML] Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell …
Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2
(VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the …
(VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the …
Data-driven identification of inherent features of eukaryotic stress-responsive genes
Living organisms are continuously challenged by changes in their environment that can
propagate to stresses at the cellular level, such as rapid changes in osmolarity or oxygen …
propagate to stresses at the cellular level, such as rapid changes in osmolarity or oxygen …