At present, gene transfection insufficient efficiency is a major drawback of non-viral gene
therapy. The 2 main types of delivery systems deployed in gene therapy are based on viral …

Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor
cells without destroying the normal tissues. While some viruses seem to have a natural …

Up to now, chitosan and DNA have been investigated for gene delivery due to chitosan
advantages. It is recognized that chitosan is a biocompatible and biodegradable non-viral …

Abstract Mutant KRAS sustained KRAS-GTP conformation and activated downstream
signaling in pancreatic cancer. Inhibition of KRAS expression has been widely utilized for …

Hydrogels with pH/temperature responsiveness and high water uptake have been
synthesized by the free radical polymerization of 2-(2-methoxyethoxy) ethyl methacrylate …

Herein, we propose the synthesis of a microspherical imprinted hydrogel meant for the
controlled release of a nucleotide, adenosine 5′-monophosphate (5′-AMP). Indeed …

Background The generation of anti-adenovirus neutralizing antibody (NAb) in humans
severely restricts the utilization of recombinant adenovirus serotype 5 (Ad5) vectors in gene …

Different transformation systems and vectors have been improved to increase the
effectiveness of transformation and achieve stable expression of target genes. Because …

Thermoresponsive cationic nanogel (TCNG) networks based on N-isopropylacrylamide
(NIPAM), 2-(dimethylamino) ethyl methacrylate (DMAEMA), and quaternary alkyl ammonium …

The present study was undertaken to investigate the effect of the composition of the
polymerization medium and the type of drug/drug loading process on the mechanical …