Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated
that enhanced BAT thermogenesis is tightly associated with increased energy expenditure …

Metabolic diseases are caused by a complex interplay between genetics and the
environment, yet many basic studies guiding our understanding of metabolism are confined …

Highlights•Adipose tissue is a heterogeneous organ that dynamically remodels in response
to stimuli.•Subtypes of white adipocytes have been identified using technologies like sNuc …

The circadian rhythm of the immune system helps to protect against pathogens 1, 2, 3;
however, the role of circadian rhythms in immune homeostasis is less well understood …

Background Accumulating evidence suggested increasing energy expenditure is a feasible
strategy for combating obesity, and browning of white adipose tissue (WAT) to promote …

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of
generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is …

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-
body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation …

Enhancing meat production and quality is the eternal theme for pig breeding industries. Fat
deposition has always been the focus of research in practical production because it is …