Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …

The Wnt signaling pathway is a conserved pathway involved in important cellular processes
such as the control of embryonic development, cellular polarity, cellular migration, and cell …

Alveologenesis is the culmination of lung development and involves the correct temporal
and spatial signals to generate the delicate gas exchange interface required for respiration …

Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of
bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or …

Abstract Development and regeneration of tissues and organs require precise coordination
among endothelial, epithelial and mesenchymal morphogenesis. Angiogenesis plays key …

Pulmonary hypertension (PH) is a devastating pulmonary vascular disease characterized by
aberrant muscularization of the normally nonmuscularized distal pulmonary arterioles. The …

Currently, more than 9 million American adults, including women of childbearing age, use
electronic-cigarettes (e-cigs). Further, the prevalence of maternal vaping now approaching …

Mitochondria contribute to key processes of cellular function, while mitochondrial
dysfunction is implicated in metabolic disorders, neurodegenerative diseases, and …

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in
infants caused by pre-and/or postnatal lung injury. BPD is characterized by arrested …

The development of neonatal chronic lung disease (nCLD), ie, bronchopulmonary dysplasia
(BPD) in preterm infants, significantly determines long-term outcome in this patient …