The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Present variants of concern and variants of interest of severe acute respiratory syndrome coronavirus 2: their significant mutations in S‐glycoprotein, infectivity, re …

C Chakraborty, M Bhattacharya… - Reviews in Medical …, 2022 - Wiley Online Library
Newly arising variants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
are now a threat to global public health and are creating COVID‐19 surges in different …

Infection of wild-type mice by SARS-CoV-2 B. 1.351 variant indicates a possible novel cross-species transmission route

T Pan, R Chen, X He, Y Yuan, X Deng, R Li… - Signal transduction and …, 2021 - nature.com
COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-
transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable …

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
requires effective therapies against coronavirus disease 2019 (COVID-19), and neutralizing …

[HTML][HTML] Clinical characteristics, transmissibility, pathogenicity, susceptible populations, and re-infectivity of prominent COVID-19 variants

Z Yang, S Zhang, YP Tang, S Zhang, DQ Xu… - Aging and …, 2022 - ncbi.nlm.nih.gov
In addition to the rapid, global spread of SARS-CoV-2, new and comparatively more
contagious variants are of considerable concern. These emerging mutations have become a …

Understanding the secret of SARS-CoV-2 variants of concern/interest and immune escape

F Lou, M Li, Z Pang, L Jiang, L Guan, L Tian… - Frontiers in …, 2021 - frontiersin.org
The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public …

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2

J Prévost, J Richard, R Gasser, S Ding, C Fage… - Journal of Biological …, 2021 - ASBMB
The seasonal nature of outbreaks of respiratory viral infections with increased transmission
during low temperatures has been well established. Accordingly, temperature has been …

A comprehensive overview on COVID-19: future perspectives

R Rana, A Tripathi, N Kumar… - Frontiers in Cellular and …, 2021 - frontiersin.org
The outbreak of COVID-19 has proven to be an unprecedented disaster for the whole world.
The virus has inflicted billion of lives across the globe in all aspects—physically …

Neutralization of SARS-CoV-2 variants of concern harboring Q677H

C Zeng, JP Evans, JN Faraone, P Qu, YM Zheng, L Saif… - MBio, 2021 - Am Soc Microbiol
The sensitivity of SARS-CoV-2 variants of concern (VOCs) to neutralizing antibodies has
largely been studied in the context of key receptor binding domain (RBD) mutations …

Emergence of a recurrent insertion in the N-terminal domain of the SARS-CoV-2 spike glycoprotein

M Gerdol, K Dishnica, A Giorgetti - Virus research, 2022 - Elsevier
Tracking the evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) through genomic surveillance programs is undoubtedly one of the key priorities in the …