The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Three-dimensional (3D) bioprinting of vascular tissues that are mechanically and
functionally comparable to their native counterparts is an unmet challenge. Here, we …

Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound
healing. Materials can be engineered to deliver specific biological cues that enhance …

Endogenous electric fields (EF) are the basis of bioelectric signal conduction and the priority
signal for damaged tissue regeneration. Tissue exudation directly affects the characteristics …

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Silk fibroin (SF) and sericin (SS), the two major proteins of silk, are attractive biomaterials
with great potential in tissue engineering and regenerative medicine. However, their …