[HTML][HTML] Notch signaling pathway: architecture, disease, and therapeutics
B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Microfluidic bioprinting of tough hydrogel-based vascular conduits for functional blood vessels
Three-dimensional (3D) bioprinting of vascular tissues that are mechanically and
functionally comparable to their native counterparts is an unmet challenge. Here, we …
functionally comparable to their native counterparts is an unmet challenge. Here, we …
[HTML][HTML] The role of microenvironment in tumor angiogenesis
X Jiang, J Wang, X Deng, F Xiong, S Zhang… - Journal of Experimental …, 2020 - Springer
Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …
and plays an important role in their growth, invasion, and metastasis. The tumor …
[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
Engineering bacteria‐activated multifunctionalized hydrogel for promoting diabetic wound healing
Y Lu, H Li, J Wang, M Yao, Y Peng, T Liu… - Advanced Functional …, 2021 - Wiley Online Library
Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound
healing. Materials can be engineered to deliver specific biological cues that enhance …
healing. Materials can be engineered to deliver specific biological cues that enhance …
Endogenous electric‐field‐coupled electrospun short fiber via collecting wound exudation
J Wang, J Lin, L Chen, L Deng, W Cui - Advanced Materials, 2022 - Wiley Online Library
Endogenous electric fields (EF) are the basis of bioelectric signal conduction and the priority
signal for damaged tissue regeneration. Tissue exudation directly affects the characteristics …
signal for damaged tissue regeneration. Tissue exudation directly affects the characteristics …
[HTML][HTML] Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
[HTML][HTML] Shaping the brain vasculature in development and disease in the single-cell era
T Wälchli, J Bisschop, P Carmeliet, G Zadeh… - Nature Reviews …, 2023 - nature.com
The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
Silk fibroin and sericin differentially potentiate the paracrine and regenerative functions of stem cells through multiomics analysis
Y Zhang, R Sheng, J Chen, H Wang, Y Zhu… - Advanced …, 2023 - Wiley Online Library
Silk fibroin (SF) and sericin (SS), the two major proteins of silk, are attractive biomaterials
with great potential in tissue engineering and regenerative medicine. However, their …
with great potential in tissue engineering and regenerative medicine. However, their …