Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle

J Wang, D Sun, M Wang, A Cheng, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …

Dysregulation and therapeutic targeting of RNA splicing in cancer

RF Stanley, O Abdel-Wahab - Nature cancer, 2022 - nature.com
High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)

HE Salapa, PA Thibault, CD Libner, Y Ding… - Nature …, 2024 - nature.com
Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS)
resulting in permanent disability, creating an urgent need to discover its underlying …

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Y Lu, X Wang, Q Gu, J Wang, Y Sui, J Wu… - Cell Death Discovery, 2022 - nature.com
Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of
the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 …

Tumor-promoting actions of HNRNP A1 in HCC are associated with cell cycle, mitochondrial dynamics, and necroptosis

B Zhao, X Lv, X Zhao, S Maimaitiaili, Y Zhang… - International Journal of …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies in the world.
Although increasing evidence supports the role of heterogeneous ribonucleoprotein particle …

Pathological phase transitions in ALS-FTD impair dynamic RNA–protein granules

NB Nedelsky, JP Taylor - Rna, 2022 - rnajournal.cshlp.org
The genetics of human disease serves as a robust and unbiased source of insight into
human biology, both revealing fundamental cellular processes and exposing the …

Knock-down of heterogeneous nuclear ribonucleoprotein A1 results in neurite damage, altered stress granule biology, and cellular toxicity in differentiated neuronal …

A Anees, HE Salapa, PA Thibault, C Hutchinson… - eneuro, 2021 - eneuro.org
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an RNA binding protein (RBP)
that is localized within neurons and plays crucial roles in RNA metabolism. Its importance in …

The virus–host interplay in Junín mammarenavirus infection

GL Gallo, N López, ME Loureiro - Viruses, 2022 - mdpi.com
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of
Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas …

Protein thermal sensing regulates physiological amyloid aggregation

D Marijan, EA Momchilova, D Burns… - Nature …, 2024 - nature.com
To survive, cells must respond to changing environmental conditions. One way that
eukaryotic cells react to harsh stimuli is by forming physiological, RNA-seeded subnuclear …

[HTML][HTML] Autoimmunity to a ribonucleoprotein drives neuron loss in multiple sclerosis models

CD Libner, HE Salapa, C Hutchinson, TE Stang… - Neurobiology of …, 2022 - Elsevier
Neurodegeneration, the progressive loss or damage to neurons and axons, underlies
permanent disability in multiple sclerosis (MS); yet its mechanisms are incompletely …