Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …

Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

With the aging of the population intensifying, finding a cure or reasonable treatment for
Alzheimer'disease (AD) has become an urgent priority. To target the multi-facets of AD, a …

Alzheimer's disease (AD) is the most common type of dementia, the exact etiology of the
disease has not been known yet. The use of single-target drugs limits the efficacy of drugs …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
different pathogenic mechanisms. In this regard, the goal of this study was the design and …

The abundance, low cost, high density of functional groups and ease of purification of
carbohydrates are among the most important features that make them a prime candidate for …

A new series of eight multifunctional thalidomide–donepezil hybrids were synthesized
based on the multi-target-directed ligand strategy and evaluated as potential …

A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was
synthesized and evaluated as multifunctional ligands against neurodegenerative diseases …

A series of amino acid-derived 1, 2, 3-triazoles presenting the amino acid residue and the
benzazole fluorophore connected by a triazole-4-carboxylate spacer was studied for …

Among the most recent proposals regarding the mechanism of action of dipyrone, the
modulation of cannabinoid receptors CB1 and CB2 appears to be a promising hypothesis. In …