Determinants, maintenance, and function of organellar pH

SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

M Forgac - Nature reviews Molecular cell biology, 2007 - nature.com
The acidity of intracellular compartments and the extracellular environment is crucial to
various cellular processes, including membrane trafficking, protein degradation, bone …

The V-type H+ ATPase: molecular structure and function,physiological roles and regulation

KW Beyenbach, H Wieczorek - Journal of Experimental …, 2006 - journals.biologists.com
It was nearly 30 years before the V-type H+ ATPase was admitted to the small circle of bona
fide transport ATPases alongside F-type and P-type ATPases. The V-type H+ ATPase is an …

Vacuolar transporters and their essential role in plant metabolism

E Martinoia, M Maeshima… - Journal of experimental …, 2007 - academic.oup.com
Following the unequivocal demonstration that plants contain at least two types of vacuoles,
scientists studying this organelle have realized that the plant 'vacuome'is far more complex …

Regulation and isoform function of the V-ATPases

M Toei, R Saum, M Forgac - Biochemistry, 2010 - ACS Publications
The vacuolar (H+)-ATPases are ATP-dependent proton pumps that acidify intracellular
compartments and, in some cases, transport protons across the plasma membrane of …

Linear artificial molecular muscles

Y Liu, AH Flood, PA Bonvallet, SA Vignon… - Journal of the …, 2005 - ACS Publications
Two switchable, palindromically constituted bistable [3] rotaxanes have been designed and
synthesized with a pair of mechanically mobile rings encircling a single dumbbell. These …

[HTML][HTML] Regulation and function of V-ATPases in physiology and disease

MP Collins, M Forgac - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020 - Elsevier
Abstract The vacuolar H+-ATPases (V-ATPases) are essential, ATP-dependent proton
pumps present in a variety of eukaryotic cellular membranes. Intracellularly, V-ATPase …

The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase

PM Kane - Microbiology and Molecular Biology Reviews, 2006 - Am Soc Microbiol
All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in
organelle acidification. Not only is the structure of V-ATPases highly conserved among …

Renal Vacuolar H+-ATPase

CA Wagner, KE Finberg, S Breton… - Physiological …, 2004 - journals.physiology.org
Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent
transport of protons. In addition to their role in acidifying the lumen of various intracellular …

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

C Wang, T Zhao, Y Li, G Huang, MA White… - Advanced drug delivery …, 2017 - Elsevier
Endosomes and lysosomes play a critical role in various aspects of cell physiology such as
nutrient sensing, receptor recycling, protein/lipid catabolism, and cell death. In drug delivery …