Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Molecular targeting therapies for neuroblastoma: Progress and challenges
There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
[HTML][HTML] The MYCN protein in health and disease
MV Ruiz-Pérez, AB Henley, M Arsenian-Henriksson - Genes, 2017 - mdpi.com
MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor,
MYCN, involved in the control of fundamental processes during embryonal development …
MYCN, involved in the control of fundamental processes during embryonal development …
[HTML][HTML] Integrative discovery of treatments for high-risk neuroblastoma
Despite advances in the molecular exploration of paediatric cancers, approximately 50% of
children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options …
children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options …
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling
J Dzieran, A Rodriguez Garcia… - Proceedings of the …, 2018 - National Acad Sciences
Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic
nervous system with clinical behavior ranging from spontaneous regression to poorly …
nervous system with clinical behavior ranging from spontaneous regression to poorly …
[HTML][HTML] Molecular mechanisms and therapeutic targets in neuroblastoma
JI Johnsen, C Dyberg, S Fransson… - Pharmacological research, 2018 - Elsevier
Neuroblastoma is the most common extracranical tumor of childhood and the most deadly
tumor of infancy. It is characterized by early age onset and high frequencies of metastatic …
tumor of infancy. It is characterized by early age onset and high frequencies of metastatic …
[HTML][HTML] MYCN-enhanced oxidative and glycolytic metabolism reveals vulnerabilities for targeting neuroblastoma
G Oliynyk, MV Ruiz-Pérez, L Sainero-Alcolado… - Iscience, 2019 - cell.com
In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new
treatment options are needed for these patients. Identifying the metabolic adaptations crucial …
treatment options are needed for these patients. Identifying the metabolic adaptations crucial …
[HTML][HTML] The oncogenic relevance of miR-17-92 cluster and its paralogous miR-106b-25 and miR-106a-363 clusters in brain tumors
R Gruszka, M Zakrzewska - International journal of molecular sciences, 2018 - mdpi.com
The fundamental function of ribonucleic acids is to transfer genetic information from DNA to
protein during translation process, however, this is not the only way connecting active RNA …
protein during translation process, however, this is not the only way connecting active RNA …
[HTML][HTML] Molecularly targeted therapy for neuroblastoma
EG Greengard - Children, 2018 - mdpi.com
Neuroblastoma is the most common extra-cranial solid tumor encountered in childhood and
accounts for 15% of pediatric cancer-related deaths. Although there has been significant …
accounts for 15% of pediatric cancer-related deaths. Although there has been significant …
[HTML][HTML] Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
L Sainero-Alcolado, M Mushtaq, J Liaño-Pons… - Journal of Experimental …, 2022 - Springer
Background Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous
system, presents with heterogeneous clinical behavior. While some tumors regress …
system, presents with heterogeneous clinical behavior. While some tumors regress …