Simple Summary Prostate-specific membrane antigen (PSMA) is a transmembrane protein
that is overexpressed in prostate cancer and correlates with the aggressiveness of the …

Simple Summary The expression of the cysteine–glutamate cotransporter, system xc−, is
increased in cancer cells across many cancer types. Imaging system xc− provides new …

Abstract APR-246 (eprenetapopt) is in clinical development with a focus on hematologic
malignancies and is promoted as a mutant-p53 reactivation therapy. Currently, the detection …

Radiopharmaceuticals targeting prostate-specific membrane antigens (PSMA) are essential
for the diagnosis, evaluation, and treatment of prostate cancer (PCa), particularly metastatic …

Amino acid utilization is perturbed in cancer cells, which rewire their metabolism to support
cell survival and proliferation. This metabolic reprogramming can be exploited for diagnostic …

Abstract Purpose (S)-4-(3-18 F-Fluoropropyl)-ʟ-Glutamic Acid ([18 F] FSPG) is a
radiolabeled non-natural amino acid that is used for positron emission tomography (PET) …

Argininosuccinate lyase (ASL) is a key enzyme integral to the hepatic urea cycle which is
required for ammonia detoxification, and the citrulline-nitric oxide (NO) cycle for NO …

Cancer stem cells (CSCs) represent both a key driving force and therapeutic target of
tumoral carcinogenesis, tumor evolution, progression, and recurrence. CSC-guided tumor …

Inflammation is one key process in driving cellular redox homeostasis toward oxidative
stress, which perpetuates inflammation. In the brain, this interplay results in a vicious cycle of …

Background 18F-fluorodeoxyglucose (FDG) PET/CT is recommended for evaluation of
intermediate-risk indeterminate pulmonary nodules (IPNs). While highly sensitive, the …