Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

In the face of increasing CO2 emissions from conventional energy (gasoline), and the
anticipated scarcity of crude oil, a worldwide effort is underway for cost-effective renewable …

Polydimethylsiloxane (PDMS) has become a popular material in microfluidic and
macroscale in vitro models due to its elastomeric properties and versatility. PDMS-based …

The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay
platforms for efficient discovery and development of antivirals and disease-modulating …

For a comprehensive understanding of cells or tissues, it is important to enable multiple
studies under the controllable microenvironment of a chip. In this report, we present an …

Living systems face a fundamental challenge of orchestrating exchange of nutrients and
oxygen throughout 3D space in order to satisfy their metabolic needs.[1] In nature, vascular …

A simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS) is
presented. A coating of liquid PDMS is applied on the walls of rectangular microchannels …

Functional endothelialized networks constitute a critical building block for vascularized
replacement tissues, organ assist devices, and laboratory tools for in vitro discovery and …

One of the principal challenges in artificial lung technology has been the ability to provide
levels of oxygen and carbon dioxide exchange that rival those of the natural human lung …

In this article, we introduce a rapid and simple fabrication method to realize a 3-dimensional
(3-D) microfluidic channel with a near-perfect circular cross section. This new concept of …