Chemical derivatization of natural products: Semisynthesis and pharmacological aspects-A decade update
Natural products and their semisynthetic derivatives continue to be an important source of
potential drug leads. Natural products and their analogues structures possess the …
potential drug leads. Natural products and their analogues structures possess the …
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
MC Marrone, A Morabito, M Giustizieri… - Nature …, 2017 - nature.com
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …
Sphingolipid/ceramide pathways and autophagy in the onset and progression of melanoma: Novel therapeutic targets and opportunities
M Lai, V La Rocca, R Amato, G Freer… - International journal of …, 2019 - mdpi.com
Melanoma is a malignant tumor deriving from neoplastic transformation of melanocytes. The
incidence of melanoma has increased dramatically over the last 50 years. It accounts for …
incidence of melanoma has increased dramatically over the last 50 years. It accounts for …
[PDF][PDF] Convenient and robust metal-free synthesis of benzazole-2-ones through the reaction of aniline derivatives and sodium cyanate in aqueous medium
E Vessally, S Mohammadi, M Abdoli… - Iranian Journal of …, 2020 - ijcce.ac.ir
Benzazole-2-one derivatives are of wide interest because of their diverse biological
activities and clinical applications. Their core ring system is present in many drugs …
activities and clinical applications. Their core ring system is present in many drugs …
Reductive coupling of benzyl oxalates with highly functionalized alkyl bromides by nickel catalysis
XB Yan, CL Li, WJ Jin, P Guo, XZ Shu - Chemical science, 2018 - pubs.rsc.org
Coupling reactions involving non-sulfonated C–O electrophiles provide a promising method
for forming C–C bonds, but the incorporation of functionalized or secondary alkyl groups …
for forming C–C bonds, but the incorporation of functionalized or secondary alkyl groups …
Palladium-Catalyzed regioselective asymmetric chemodivergent allylation of oxazolones with Morita–Baylis–Hillman Adducts
R Zhang, Z Liu, Y Liu, H Yang, X Wang, Z Han… - CCS …, 2023 - chinesechemsoc.org
Oxazolones are structural subunits in numerous natural products and designed molecules
with substantial pharmacological properties. Here, a palladium-catalyzed chemodivergent …
with substantial pharmacological properties. Here, a palladium-catalyzed chemodivergent …
Iron-catalyzed arene C–H amidation using functionalized hydroxyl amines at room temperature
AVG Prasanthi, S Begum, HK Srivastava… - ACS …, 2018 - ACS Publications
Herein, we report Fe (III)(TPP) Cl as an effective catalyst for promoting arene C–H amidation
through intramolecular cyclization of N-tosyloxyarylcarbamate substrates. The reaction …
through intramolecular cyclization of N-tosyloxyarylcarbamate substrates. The reaction …
[HTML][HTML] Acid ceramidase and the treatment of ceramide diseases: The expanding role of enzyme replacement therapy
EH Schuchman - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Ceramides are a diverse group of sphingolipids that play important roles in many biological
processes. Acid ceramidase (AC) is one key enzyme that regulates ceramide metabolism …
processes. Acid ceramidase (AC) is one key enzyme that regulates ceramide metabolism …
Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O2 at Elevated Temperatures and Pressures
A continuous-flow Pd-catalyzed oxidative carbonylation protocol utilizing CO and O2 gas for
the synthesis of carbonylated heterocycles is described. The optimization of temperature …
the synthesis of carbonylated heterocycles is described. The optimization of temperature …
Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents
M Safakish, Z Hajimahdi, R Zabihollahi… - Medicinal Chemistry …, 2017 - Springer
A new class of 2-benzoxazolinone derivatives was designed and synthesized for its anti-
human immunodeficiency virus-1 activity. The benzoxazolinone scaffold could be replaced …
human immunodeficiency virus-1 activity. The benzoxazolinone scaffold could be replaced …