Natural products and their semisynthetic derivatives continue to be an important source of
potential drug leads. Natural products and their analogues structures possess the …

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …

Melanoma is a malignant tumor deriving from neoplastic transformation of melanocytes. The
incidence of melanoma has increased dramatically over the last 50 years. It accounts for …

Benzazole-2-one derivatives are of wide interest because of their diverse biological
activities and clinical applications. Their core ring system is present in many drugs …

Coupling reactions involving non-sulfonated C–O electrophiles provide a promising method
for forming C–C bonds, but the incorporation of functionalized or secondary alkyl groups …

Oxazolones are structural subunits in numerous natural products and designed molecules
with substantial pharmacological properties. Here, a palladium-catalyzed chemodivergent …

Herein, we report Fe (III)(TPP) Cl as an effective catalyst for promoting arene C–H amidation
through intramolecular cyclization of N-tosyloxyarylcarbamate substrates. The reaction …

Ceramides are a diverse group of sphingolipids that play important roles in many biological
processes. Acid ceramidase (AC) is one key enzyme that regulates ceramide metabolism …

A continuous-flow Pd-catalyzed oxidative carbonylation protocol utilizing CO and O2 gas for
the synthesis of carbonylated heterocycles is described. The optimization of temperature …

A new class of 2-benzoxazolinone derivatives was designed and synthesized for its anti-
human immunodeficiency virus-1 activity. The benzoxazolinone scaffold could be replaced …