Chemistry of Ni2+ in Urease: Sensing, Trafficking, and Catalysis
Transition metals are both essential to enzymatic catalysis and limited in environmental
availability. These two biological facts have together driven organisms to evolve …
availability. These two biological facts have together driven organisms to evolve …
Frontiers of metal-coordinating drug design
Introduction: The occurrence of metal ions in biomolecules is required to exert vital cellular
functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors …
functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors …
Nickel and human health
B Zambelli, S Ciurli - Interrelations between essential metal ions and …, 2013 - Springer
This review focuses on the impact of nickel on human health. In particular, the dual nature of
nickel as an essential as well as toxic element in nature is described, and the main forms of …
nickel as an essential as well as toxic element in nature is described, and the main forms of …
Allosteric control of metal-responsive transcriptional regulators in bacteria
Many transition metals are essential trace nutrients for living organisms, but they are also
cytotoxic in high concentrations. Bacteria maintain the delicate balance between metal …
cytotoxic in high concentrations. Bacteria maintain the delicate balance between metal …
Specific metal recognition in nickel trafficking
KA Higgins, CE Carr, MJ Maroney - Biochemistry, 2012 - ACS Publications
Nickel is an essential metal for a number of bacterial species that have developed systems
for acquiring, delivering, and incorporating the metal into target enzymes and controlling the …
for acquiring, delivering, and incorporating the metal into target enzymes and controlling the …
Nickel-responsive transcriptional regulators
Nickel is an essential micronutrient for a large number of living organisms, but it is also a
toxic metal ion when it accumulates beyond the sustainable level as it may result if and …
toxic metal ion when it accumulates beyond the sustainable level as it may result if and …
Mechanistic insights into the nickel-dependent allosteric response of the Helicobacter pylori NikR transcription factor
In Helicobacter pylori, the nickel-responsive NikR transcription factor plays a key role in
regulating intracellular nickel concentrations, which is an essential process for survival of …
regulating intracellular nickel concentrations, which is an essential process for survival of …
Role of the N-terminus in Determining Metal-Specific Responses in the E. coli Ni- and Co-Responsive Metalloregulator, RcnR
KA Higgins, PT Chivers… - Journal of the American …, 2012 - ACS Publications
RcnR (r esistance to c obalt and n ickel r egulator) is a 40-kDa homotetrameric protein and
metalloregulator that controls the transcription of the Co (II) and Ni (II) exporter, RcnAB, by …
metalloregulator that controls the transcription of the Co (II) and Ni (II) exporter, RcnAB, by …
Insights into the Allosteric Response to Acidity by the Helicobacter pylori NikR Transcription Factor
Helicobacter pylori NikR (HpNikR) is a nickel-responsive transcription factor that regulates
genes involved in nickel homeostasis, which is essential for the survival of this pathogen …
genes involved in nickel homeostasis, which is essential for the survival of this pathogen …
Computing metal‐binding proteins for therapeutic benefit
Over one third of biomolecules rely on metal ions to exert their cellular functions. Metal ions
can play a structural role by stabilizing the structure of biomolecules, a functional role by …
can play a structural role by stabilizing the structure of biomolecules, a functional role by …