The HSP90 family: structure, regulation, function, and implications in health and disease
A Hoter, ME El-Sabban, HY Naim - International journal of molecular …, 2018 - mdpi.com
The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …
involved in myriad cellular processes. Their distribution in various cellular compartments …
The HSP90 chaperone machinery
FH Schopf, MM Biebl, J Buchner - Nature reviews Molecular cell biology, 2017 - nature.com
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis
under both physiological and stress conditions in eukaryotic cells. As HSP90 has several …
under both physiological and stress conditions in eukaryotic cells. As HSP90 has several …
Hsp90: structure and function
SE Jackson - Molecular chaperones, 2013 - Springer
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …
role in many cellular processes including cell cycle control, cell survival, hormone and other …
Allosteric modulators of HSP90 and HSP70: dynamics meets function through structure-based drug design
Molecular chaperones HSP90 and HSP70 are essential regulators of the folding and
activation of a disparate ensemble of client proteins. They function through ATP hydrolysis …
activation of a disparate ensemble of client proteins. They function through ATP hydrolysis …
Allosteric modulation of human Hsp90α conformational dynamics
DL Penkler, C Atilgan… - Journal of Chemical …, 2018 - ACS Publications
Central to Hsp90's biological function is its ability to interconvert between various
conformational states. Drug targeting of Hsp90's regulatory mechanisms, including its …
conformational states. Drug targeting of Hsp90's regulatory mechanisms, including its …
[HTML][HTML] Paralog specific Hsp90 inhibitors–a brief history and a bright future
DT Gewirth - Current topics in medicinal chemistry, 2016 - ncbi.nlm.nih.gov
Background The high sequence and structural homology among the hsp90 paralogs–
Hsp90α, Hsp90β, Grp94, and Trap-1–has made the development of paralog-specific …
Hsp90α, Hsp90β, Grp94, and Trap-1–has made the development of paralog-specific …
Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi
A Roy, R Tamuli - Archives of Microbiology, 2022 - Springer
The heat shock proteins (Hsps) act as a molecular chaperone to stabilize client proteins
involved in various cell functions in fungi. Hsps are classified into different families such as …
involved in various cell functions in fungi. Hsps are classified into different families such as …
Molecular Chaperones of Leishmania: Central Players in Many Stress‐Related and ‐Unrelated Physiological Processes
JM Requena, AM Montalvo… - BioMed research …, 2015 - Wiley Online Library
Molecular chaperones are key components in the maintenance of cellular homeostasis and
survival, not only during stress but also under optimal growth conditions. Folding of nascent …
survival, not only during stress but also under optimal growth conditions. Folding of nascent …
Drug screening for discovery of broad-spectrum agents for soil-transmitted nematodes
Abstract Soil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids,
are extremely common parasites, infecting 1–2 billion of the poorest people worldwide. Two …
are extremely common parasites, infecting 1–2 billion of the poorest people worldwide. Two …
Heat shock protein 90: biological functions, diseases, and therapeutic targets
H Wei, Y Zhang, Y Jia, X Chen, T Niu, A Chatterjee… - MedComm, 2024 - Wiley Online Library
Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …