The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …

This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …

In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Protein synthesis is principally regulated at the initiation stage (rather than during elongation
or termination), allowing rapid, reversible and spatial control of gene expression. Progress …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Understanding translational control in gene expression relies on precise and
comprehensive determination of translation initiation sites (TIS) across the entire …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently
emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A …

Translation initiation in eukaryotes is a complex and highly regulated process requiring the
action of at least 12 protein factors. The pathway is distinguished by the formation of a pre …