Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are
transcribed from a large portion of the mammalian genome. While hypothesized to have a …

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …

Thousands of long noncoding RNAs (lncRNAs) are actively transcribed in mammalian
genomes. This class of RNAs has important regulatory functions in a broad range of cellular …

Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to
proliferative phenotype is a pathological hallmark in various cardiovascular diseases …

BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …

The recent discovery of vast non-coding RNA-based regulatory networks that can be easily
modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities …