Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
The majority of colorectal cancer patients are not responsive to immune checkpoint
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …
Emerging functions of human IFIT proteins in cancer
Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …
LncRNA IFITM4P promotes immune escape by up-regulating PD-L1 via dual mechanism in oral carcinogenesis
L Shi, Y Yang, M Li, C Li, Z Zhou, G Tang, L Wu, Y Yao… - Molecular Therapy, 2022 - cell.com
Oral squamous cell carcinoma (OSCC), which is typically preceded by oral leukoplakia (OL),
is a common malignancy with poor prognosis. However, the signaling molecules governing …
is a common malignancy with poor prognosis. However, the signaling molecules governing …
Better together: the role of IFIT protein–protein interactions in the antiviral response
HV Mears, TR Sweeney - Journal of General Virology, 2018 - microbiologyresearch.org
The interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of antiviral
proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA …
proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA …
Colon cancer transcriptome
K Mokhtari, M Peymani, M Rashidi… - Progress in biophysics …, 2023 - Elsevier
Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …
Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner
X Peng, R Na, W Zhou, X Meng, Y Yang, S Amini… - Oncogene, 2022 - nature.com
Gasdermin D (GSDMD) has recently been identified as a cytoplasmic effector protein that
plays a central role in pyroptosis of immune cells. However, GSDMD is a universally …
plays a central role in pyroptosis of immune cells. However, GSDMD is a universally …
Essential contribution of the JAK/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID‑19
W Li, Y Zhuang, SJ Shao, P Trivedi… - Molecular …, 2024 - spandidos-publications.com
The intracellular pathway of Janus kinase/signal transducer and activator of transcription
(JAK/STAT) and modification of nucleosome histone marks regulate the expression of …
(JAK/STAT) and modification of nucleosome histone marks regulate the expression of …
Baicalein suppresses stem cell-like characteristics in radio-and chemoresistant MDA-MB-231 human breast cancer cells through up-regulation of IFIT2
Resistance to both chemotherapy and radiation therapy is frequent in triple-negative breast
cancer (TNBC) patients. We established treatment-resistant TNBC MDA-MB-231/IR cells by …
cancer (TNBC) patients. We established treatment-resistant TNBC MDA-MB-231/IR cells by …
Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa‐miR‐1184 and releasing AJUBA and inactivating Hippo/YAP signalling
X Wang, Y Chen, W Liu, T Liu… - Journal of Cellular and …, 2020 - Wiley Online Library
Hsa_circ_0128846 was found to be the most significantly up‐regulated circRNA in our
bioinformatics analysis. However, the role of hsa_circ_0128846 in colorectal cancer has not …
bioinformatics analysis. However, the role of hsa_circ_0128846 in colorectal cancer has not …