Neuron tracing from light microscopy images: automation, deep learning and bench testing

Y Liu, G Wang, GA Ascoli, J Zhou, L Liu - Bioinformatics, 2022 - academic.oup.com
Motivation Large-scale neuronal morphologies are essential to neuronal typing, connectivity
characterization and brain modeling. It is widely accepted that automation is critical to the …

Automated neuron tracing methods: an updated account

L Acciai, P Soda, G Iannello - Neuroinformatics, 2016 - Springer
The reconstruction of neuron morphology allows to investigate how the brain works, which is
one of the foremost challenges in neuroscience. This process aims at extracting the …

BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

L Manubens-Gil, Z Zhou, H Chen, A Ramanathan… - Nature …, 2023 - nature.com
BigNeuron is an open community bench-testing platform with the goal of setting open
standards for accurate and fast automatic neuron tracing. We gathered a diverse set of …

Deep learning segmentation of optical microscopy images improves 3-D neuron reconstruction

R Li, T Zeng, H Peng, S Ji - IEEE transactions on medical …, 2017 - ieeexplore.ieee.org
Digital reconstruction, or tracing, of 3-D neuron structure from microscopy images is a critical
step toward reversing engineering the wiring and anatomy of a brain. Despite a number of …

[HTML][HTML] TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain

Y Wang, Q Li, L Liu, Z Zhou, Z Ruan, L Kong… - Nature …, 2019 - nature.com
Neuron morphology is recognized as a key determinant of cell type, yet the quantitative
profiling of a mammalian neuron's complete three-dimensional (3-D) morphology remains …

3D neuron reconstruction in tangled neuronal image with deep networks

Q Li, L Shen - IEEE transactions on medical imaging, 2019 - ieeexplore.ieee.org
Digital reconstruction or tracing of 3D neuron is essential for understanding the brain
functions. While existing automatic tracing algorithms work well for the clean neuronal image …

3D neuron microscopy image segmentation via the ray-shooting model and a DC-BLSTM network

Y Jiang, W Chen, M Liu, Y Wang… - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
The morphology reconstruction (tracing) of neurons in 3D microscopy images is important to
neuroscience research. However, this task remains very challenging because of the low …

A structural average of labeled merge trees for uncertainty visualization

L Yan, Y Wang, E Munch… - IEEE transactions on …, 2019 - ieeexplore.ieee.org
Physical phenomena in science and engineering are frequently modeled using scalar fields.
In scalar field topology, graph-based topological descriptors such as merge trees, contour …

Rivulet: 3D neuron morphology tracing with iterative back-tracking

S Liu, D Zhang, S Liu, D Feng, H Peng, W Cai - Neuroinformatics, 2016 - Springer
The digital reconstruction of single neurons from 3D confocal microscopic images is an
important tool for understanding the neuron morphology and function. However the accurate …

[HTML][HTML] DeepNeuron: an open deep learning toolbox for neuron tracing

Z Zhou, HC Kuo, H Peng, F Long - Brain informatics, 2018 - Springer
Abstract Reconstructing three-dimensional (3D) morphology of neurons is essential for
understanding brain structures and functions. Over the past decades, a number of neuron …