Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
The incessant resistivity of pathogenic microbes to antibiotics continuously constitutes a
major threat to human wellness, thus, searching for effective therapeutic approaches …
major threat to human wellness, thus, searching for effective therapeutic approaches …
Penicillin binding proteins and β-lactamases of Mycobacterium tuberculosis: reexamination of the historical paradigm
Penicillin binding proteins (PBPs) have been extensively studied due to their importance to
the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used …
the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used …
Occurrence of blaNDM-1, blaNDM-5, blaNDM-7, and blaKPC-2 genes in clinical isolates of enterobacterales with high genetic variability, from colonization …
LR Martins, MIS Pimentel, ÉM de Oliveira… - Journal of Applied …, 2024 - academic.oup.com
Aims This study aimed to investigate the presence of beta-lactams resistance genes and the
clonal relationship of clinical isolates of Enterobacterales obtained from patients with and …
clonal relationship of clinical isolates of Enterobacterales obtained from patients with and …
Involvement of the non-active site residues in the catalytic activity of NDM-4 metallo beta-lactamase
Abstract The rise of New Delhi metallo beta-lactamase (NDM) producing bacteria imposes a
significant threat to the treatment of bacterial infections due to their broad spectrum against …
significant threat to the treatment of bacterial infections due to their broad spectrum against …
Deciphering the role of residues in the loops nearing the active site of OXA-58 in imparting beta-lactamase activity
The existence of OXA-58 carbapenemase alone or in combination with other beta-lactam
resistance factors poses significant beta-lactam resistance. The exact mechanism of action …
resistance factors poses significant beta-lactam resistance. The exact mechanism of action …
Two non-active site residues W165 and L166 prominently influence the beta-lactam hydrolytic ability of OXA-23 beta-lactamase
D Jain, J Verma, T Ajith, A Bhattacharjee… - The Journal of …, 2023 - nature.com
Dissemination of class D OXA-type carbapenemases is one of the significant causes of beta-
lactam resistance in Gram-negative bacteria. The amino acid residues present near the …
lactam resistance in Gram-negative bacteria. The amino acid residues present near the …