Systemic anaplastic large cell lymphoma (ALCL) is an aggressive CD30+ non-Hodgkin
lymphoma. Anaplastic lymphoma kinase–positive (ALK+) ALCL is associated with the NPM …

Anaplastic large cell lymphoma (ALCL) represents a generally recognized group of large
cell lymphomas. Defining features consist of a proliferation of predominantly large lymphoid …

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues is the second
volume of the 4th Edition of the WHO series on histological and genetic typing of human …

Background Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent
nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations …

This is the third volume in the new World Health Organization series on histological and
genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered …

Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations
featuring an inflammatory infiltrate composed primarily of lymphocytes and plasma cells. The …

The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

A fusion gene, echinoderm microtubule associated protein like 4–anaplastic lymphoma
kinase (EML4-ALK), with transforming activity has recently been identified in a subset of non …

Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant
cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the …