Abstract Introduction Phosphodiesterase type 5 (PDE-5) hydrolyzes cyclic guanylate
monophosphate (cGMP) specifically to 5′ GMP, promoting successful corporeal vascular …

Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and
pathophysiological processes. In recent years, more and more studies have uncovered …

Nitric oxide has been proven to play an important role in nociception, accordingly, its
promoters, phosphodiesterase inhibitors have been investigated as pain response …

A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐PSQ), was
described and synthetized by our research group. Recently, we demonstrated the potential …

Neuropathic pain is a chronic pain caused by a lesion or disease affecting the
somatosensory nervous system. To date, no specific treatment has been developed to cure …

Background and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …

Ethnopharmacological relevance Pain is the commonest symptom of a disease and the
percentage of persons manifesting one form of pain is growing globally. Aframomum …

Introduction New therapeutic alternatives for pain relief include the use of
phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful …

Inadequate management of neuropathic pain results in poor clinical outcomes and reduces
quality of life for the patient all over the world, but intricate interplay between wide variety of …

We studied the osteoarthritis (OA)‐modifying effects of atorvastatin in an experimental OA rat
model and possible underlining mechanisms. We used 62 adult male Sprague–Dawley rats …