Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall
glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been …

▪ Abstract This review summarizes key aspects of tetraspanin proteins, with a focus on the
functional relevance and structural features of these proteins and how they are organized …

Background During continuous ambulatory peritoneal dialysis, the peritoneum is exposed to
bioincompatible dialysis fluids that cause denudation of mesothelial cells and, ultimately …

Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by
connecting membrane adhesion receptors to the actin-based cytoskeleton. We have studied …

The first tetraspanins were discovered on surface of human leucocytes, but it was rapidly
demonstrated that they had a wider tissue expression. Twenty-six molecules display …

The transmembrane proteins of the tetraspanin superfamily are implicated in a diverse
range of biological phenomena, including cell motility, metastasis, cell proliferation and …

Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP)
activity critical for extracellular matrix turnover associated with both physiologic and …

Cutaneous wound healing is a highly coordinated physiological process that rapidly and
efficiently restores skin integrity. Reepithelization is a crucial step during wound healing …

Exciting new findings have emerged about the structure, function and biochemistry of
tetraspanin proteins. Five distinct tetraspanin regions have now been delineated linking …