Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

RBM15, an RNA binding protein, determines cell-fate specification of many tissues including
blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 …

Human leukemias are liquid malignancies characterized by diffuse infiltration of the bone
marrow by transformed hematopoietic progenitors. The accessibility of tumor cells obtained …

Hematologic malignancies represent the fourth most frequently diagnosed cancer in
economically developed countries. In hematologic malignancies normal hematopoiesis is …

The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …

Growing evidence has demonstrated that epigenetic dysregulation is a common
pathological feature in human cancer cells. Global alterations in the epigenetic landscape …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. ALL arises
from the malignant transformation of progenitor B-and T-cells in the bone marrow into …