The functional capabilities of skeletal muscle are strongly correlated with its well-arranged
microstructure, consisting of parallelly aligned myotubes. In case of extensive muscle loss …

Skeletal muscles have a robust capacity to regenerate, but under compromised conditions,
such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in …

Engineering organ-specific tissues for therapeutic applications is a grand challenge,
requiring the fabrication and maintenance of densely cellular constructs composed of~ 108 …

A bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which
mimics the structural and functional characteristics of the native tissue, is needed for …

A bioengineered skeletal muscle construct that mimics structural and functional
characteristics of native skeletal muscle is a promising therapeutic option to treat extensive …

Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …

Volumetric muscle loss (VML) is an irrecoverable injury associated with muscle loss greater
than 20%. Although hydrogel-based 3D engineered muscles and the decellularized …

The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

Generating human skeletal muscle models is instrumental for investigating muscle
pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial …

Viscoelastic hydrogels can enhance 3D cell migration and proliferation due to the faster
stress relaxation promoting the arrangement of the cellular microenvironment. However …