Typical physiological characteristics of tumors, such as weak acidity, low oxygen content,
and upregulation of certain enzymes in the tumor microenvironment (TME), provide survival …

Understanding the genomic features of livestock is essential for successful breeding
programs and conservation. This information is scarce for local goat breeds in Egypt. In the …

Alzheimer's disease (AD) is a neurodegenerative disease with multifactorial pathogenesis.
However, most current therapeutic approaches for AD target a single pathophysiological …

BACKGROUND: Perivascular adipose tissue (PVAT) is vital for vascular homeostasis, and
PVAT dysfunction is associated with increased atherosclerotic plaque burden. But the …

The disease neonatal sepsis (NS) poses a serious threat to life, and its pathogenesis
remains unclear. Using the Gene Expression Omnibus (GEO) database, differentially …

Vaccination-induced protection against influenza is greatly diminished and increasingly
heterogeneous with age. We investigated longitudinally (up to five time points) a cohort of …

Microglial endolysosomal (dys) function is strongly implicated in neurodegenerative
disease. Transcriptomic studies show that a microglial state characterised by a set of genes …

ABSTRACT INTRODUCTION In this study, we explore the role of oxidative stress produced
by NOX2-containing NADPH oxidase as a molecular mechanism causing capillary stalling …

Turner syndrome (TS) can be determined by karyotype analysis, marked by the loss of one X
chromosome in females. However, the genes involved in autoimmunity in TS patients …

B lymphocytes play an important role in the regulation of immune response in both normal
and pathological conditions. Traditionally, the main functions of B cells were considered to …