Poly (β amino esters) copolymers: Novel potential vectors for delivery of genes and related therapeutics
S Iqbal, Z Zhao - International Journal of Pharmaceutics, 2022 - Elsevier
The unique properties of polymers have performed an essential contribution to the drug
delivery system by providing an outstanding platform for the delivery of macromolecules and …
delivery system by providing an outstanding platform for the delivery of macromolecules and …
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution
Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …
resulting in market approval of numerous therapeutics predominantly relying on adeno …
An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
AB Silver, SY Tzeng, M Lager, J Wang, J Ishihara… - Cell Reports …, 2023 - cell.com
The clinical utility of human interleukin-2 (hIL-2) is limited by its short serum half-life,
preferential activation of regulatory T (T Reg) over immune effector cells, and dose-limiting …
preferential activation of regulatory T (T Reg) over immune effector cells, and dose-limiting …
Ammonium trifluoroborate-modified poly (β-aminoesters): A case study for PET-guidedin vivopharmacokinetic studies of a non-viral gene delivery system
R Cosialls, O Fernández, C Simó… - … Clinics and Research, 2023 - journals.lww.com
Nucleic acid-based therapies have become a game-changing player in our way of
conceiving pharmacology. Nevertheless, the inherent lability of the phosphodiester bond of …
conceiving pharmacology. Nevertheless, the inherent lability of the phosphodiester bond of …
Bioconjugated materials in the development of subunit vaccines
J Fan, I Toth, RJ Stephenson - Comprehensive Analytical Chemistry, 2023 - Elsevier
Vaccination is the most effective intervention for infectious diseases. Immunisation with
pathogen-derived antigens stimulate the adaptive immune response, protecting against …
pathogen-derived antigens stimulate the adaptive immune response, protecting against …
Chemically-assisted DNA transfection methods–An overview
S Bekić, S Jovanović-Šanta - Journal of the Serbian Chemical …, 2023 - shd-pub.org.rs
Non-viral chemical-based methods for in vitro cell transfection are commonly used to
incorporate foreign gene of interest into mammalian cells due to numerous benefits–high …
incorporate foreign gene of interest into mammalian cells due to numerous benefits–high …