Poly (β amino esters) copolymers: Novel potential vectors for delivery of genes and related therapeutics

S Iqbal, Z Zhao - International Journal of Pharmaceutics, 2022 - Elsevier
The unique properties of polymers have performed an essential contribution to the drug
delivery system by providing an outstanding platform for the delivery of macromolecules and …

The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution

A Kachanov, A Kostyusheva, S Brezgin… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

AB Silver, SY Tzeng, M Lager, J Wang, J Ishihara… - Cell Reports …, 2023 - cell.com
The clinical utility of human interleukin-2 (hIL-2) is limited by its short serum half-life,
preferential activation of regulatory T (T Reg) over immune effector cells, and dose-limiting …

Ammonium trifluoroborate-modified poly (β-aminoesters): A case study for PET-guidedin vivopharmacokinetic studies of a non-viral gene delivery system

R Cosialls, O Fernández, C Simó… - … Clinics and Research, 2023 - journals.lww.com
Nucleic acid-based therapies have become a game-changing player in our way of
conceiving pharmacology. Nevertheless, the inherent lability of the phosphodiester bond of …

Bioconjugated materials in the development of subunit vaccines

J Fan, I Toth, RJ Stephenson - Comprehensive Analytical Chemistry, 2023 - Elsevier
Vaccination is the most effective intervention for infectious diseases. Immunisation with
pathogen-derived antigens stimulate the adaptive immune response, protecting against …

Chemically-assisted DNA transfection methods–An overview

S Bekić, S Jovanović-Šanta - Journal of the Serbian Chemical …, 2023 - shd-pub.org.rs
Non-viral chemical-based methods for in vitro cell transfection are commonly used to
incorporate foreign gene of interest into mammalian cells due to numerous benefits–high …