Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of developing
several of the major health issues facing the western world, including neurodegenerative …

INTRODUCTION Only 2.4% of the 16.5-kb mitochondrial DNA (mtDNA) genome shows
homoplasmic variation at> 1% frequency in humans. Migration patterns have contributed to …

In nearly all eukaryotes, at least some individuals inherit mitochondrial and chloroplast
genes from only one parent. There is no single mechanism of uniparental inheritance …

Mammalian cells contain thousands of copies of mitochondrial DNA (mtDNA). At birth, these
are thought to be identical in most humans. Here, we use long read length ultra-deep …

▪ Abstract The inheritance of mitochondrial and chloroplast genes differs from that of nuclear
genes in showing vegetative segregation, uniparental inheritance, intracellular selection …

Introduction In the last 10 years the field of mitochondrial genetics has widened, shifting the
focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …

Cytoplasmic organelles are inherited in a nonMendelian fashion in all eukaryotic organisms
investigated. Among the seed plants, plastids can be inherited strictly from the female …

Mitochondrial DNA (mtDNA) is maternally inherited in mammals. Despite the high genome
copy number in mature oocytes (105) and the relatively small number of cell divisions in the …