Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …

Cellular senescence contributes to Alzheimer's disease (AD) pathogenesis. An open-label,
proof-of-concept, phase I clinical trial of orally delivered senolytic therapy, dasatinib (D) and …

Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Senescent cells contribute to pathology and dysfunction in animal models. Their sparse
distribution and heterogenous phenotype have presented challenges to their detection in …