Simple Summary Endocrine therapy is a common treatment for estrogen-responsive breast
cancer, which is used to block the tumor growth-promoting effect of this hormone. The …

Breast cancer is a major threat to women's lives throughout the world. Hormone-dependent
or estrogen-receptor positive (ER+) breast cancer accounts for more than 80% of all …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Based on the structural architecture of estrogen receptors (ER) agonists/antagonists, we
rationally designed and synthesized indenopyrimidine-2, 5-dione analogs as a starting point …

Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

Xanthine Oxidase inhibitors treat hyperuricemia, but associated side effects have led
researchers to discover new inhibitors with fewer side effects. Our study employed a hybrid …

Sulfonamides have gained prominence as versatile agents in cancer therapy, effectively
targeting a spectrum of cancer-associated enzymes. This review provides an extensive …

Hyperuricemia, a disease characterized by elevation of serum uric acid level beyond 6
mg/dL. This elevation led to appearance of symptoms from joint pain to gout and from gout to …

Cancer is a complex disease that requires multidisciplinary treatment. One of the most
common cancers is breast cancer, and these cancers are usually estrogen receptor-positive …

Breast cancer is the most diagnosed type of cancer amongst women in economically
developing countries and globally. Most breast cancers express estrogen receptor alpha …