The emergence of multidrug-resistant bacteria demands innovations in the development of
new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered …

Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective
classes of antibiotics. They are the most extensively used class of antibiotics and their …

Due to the inherent resistance of bacterial biofilms to antibiotics and their serious threat to
global public health, novel therapeutic agents and strategies to tackle biofilms are urgently …

Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant
bacteria, with vancomycin still a mainstream therapy against serious Gram-positive …

Subsequent to binding pocket modifications designed to provide dual d-Ala-d-Ala/d-Ala-d-
Lac binding that directly overcome the molecular basis of vancomycin resistance, peripheral …

New Delhi metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase
and hydrolyzes almost all clinically used β-lactam antibiotics. Here we show that the …

The application of small molecules as catalysts for the diversification of natural product
scaffolds is reviewed. Specifically, principles that relate to the selectivity challenges intrinsic …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

This study aims to synthesize new pyrrolic compounds derivatives of 8-hydroxyquinoline,
explore the structure-activity relationship and the effect of the substituents carried by the …

Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …