Design and synthesis of hybrid compounds as novel drugs and medicines
AH Alkhzem, TJ Woodman, IS Blagbrough - RSC advances, 2022 - pubs.rsc.org
The development of highly effective conjugate chemistry approaches is a way to improve the
quality of drugs and of medicines. The aim of this paper is to highlight and review such …
quality of drugs and of medicines. The aim of this paper is to highlight and review such …
Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti …
We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p)
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …
Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant …
Pharmaceuticals and personal care products (PPCPs) as emerging contaminants are
ubiquitously present in the aquatic environment. Using in vivo and in silico techniques, this …
ubiquitously present in the aquatic environment. Using in vivo and in silico techniques, this …
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency
Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …
Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors
YL Tang, X Zheng, Y Qi, XJ Pu, B Liu, X Zhang, XS Li… - Bioorganic …, 2020 - Elsevier
In this work, a series of novel chalcone derivatives bearing bispiperazine linker have been
synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory …
synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory …
Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation
N Ahmadi, M Rincón, M Silva-Abreu, L Sosa… - Gels, 2023 - mdpi.com
Pranoprofen (PRA)-loaded nanostructured lipid carriers (NLC) have been dispersed into
blank gels composed of 1% of Carbomer 940 (PRA-NLC-Car) and 3% of Sepigel® 305 …
blank gels composed of 1% of Carbomer 940 (PRA-NLC-Car) and 3% of Sepigel® 305 …
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti …
WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic Chemistry, 2024 - Elsevier
A novel series of pyrazole derivatives with urea/thiourea scaffolds 16a-l as hybrid
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
Design, synthesis and biological evaluation of antitumor platinum (II) agents conjugated with non-steroidal anti-inflammatory drug species
J Zang, B Zhang, Y Wang, X Wang, S Gou - Bioorganic Chemistry, 2022 - Elsevier
As one of the key features of tumor, inflammation attracts much attention of many
researchers for antitumor study, in which non-steroidal anti-inflammatory drugs (NSAIDs) …
researchers for antitumor study, in which non-steroidal anti-inflammatory drugs (NSAIDs) …
Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies
Novel sixteen naproxen urea compounds were synthesized bearing the thiadiazole ring.
Their inhibitory activities against tyrosinase were investigated. 3o was discovered to be the …
Their inhibitory activities against tyrosinase were investigated. 3o was discovered to be the …
Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities
Two new series of ethyl benzoate bearing pyrrolizine and indolizine moieties 8–11 were
synthesized and evaluated for their anti-inflammatory and anticancer activities. Among these …
synthesized and evaluated for their anti-inflammatory and anticancer activities. Among these …