Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth
factors. Despite the biological and therapeutic significance, the molecular mechanism of R …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

How animals establish and pattern the primary body axis is one of the most fundamental
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) …

To provide a temporal framework for the genoarchitecture of brain development, we
generated in situ hybridization data for embryonic and postnatal mouse brain at seven …

Abstract Background: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate
head organizer and induces anterior development by antagonizing Wnt signaling. Although …

Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular …

WNT signalling has a key role in early embryonic patterning through the regulation of cell
fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling …