Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease
S Hijazi, AB Smit, RE van Kesteren - Molecular Psychiatry, 2023 - nature.com
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …
morphological and functional properties that allow them to precisely control local circuitry …
Circular RNAs: emerging players in brain aging and neurodegenerative diseases
DP Wu, YD Zhao, QQ Yan, LL Liu… - The Journal of …, 2023 - Wiley Online Library
Brain aging is closely related to neurodegenerative diseases. Circular RNAs (circRNAs) are
a type of conserved RNAs with covalently closed continuous loops. Emerging evidence has …
a type of conserved RNAs with covalently closed continuous loops. Emerging evidence has …
[HTML][HTML] The aging astrocyte transcriptome from multiple regions of the mouse brain
Aging brains undergo cognitive decline, associated with decreased neuronal synapse
number and function and altered metabolism. Astrocytes regulate neuronal synapse …
number and function and altered metabolism. Astrocytes regulate neuronal synapse …
Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts
R Castro-Hernández, T Berulava… - Proceedings of the …, 2023 - National Acad Sciences
N6-methyladenosine (m6A) regulates mRNA metabolism. While it has been implicated in
the development of the mammalian brain and in cognition, the role of m6A in synaptic …
the development of the mammalian brain and in cognition, the role of m6A in synaptic …
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
G Berdugo-Vega, G Arias-Gil… - Nature …, 2020 - nature.com
Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …
Klotho controls the brain–immune system interface in the choroid plexus
L Zhu, LR Stein, D Kim, K Ho, GQ Yu… - Proceedings of the …, 2018 - National Acad Sciences
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and
forms an important barrier between the central nervous system and the blood. For unknown …
forms an important barrier between the central nervous system and the blood. For unknown …
Dual-task exercise to improve cognition and functional capacity of healthy older adults
NYV Jardim, NVO Bento-Torres, VO Costa… - Frontiers in Aging …, 2021 - frontiersin.org
Background It has been suggested that physical inactivity and lack of stimulating cognitive
activity are the two most significant modifiable risk factors to impair cognitive function …
activity are the two most significant modifiable risk factors to impair cognitive function …
Polyunsaturated fatty acids and endocannabinoids in health and disease
HR Freitas, AR Isaac, R Malcher-Lopes… - Nutritional …, 2018 - Taylor & Francis
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …
Identifying changepoints in biomarkers during the preclinical phase of Alzheimer's disease
Objective: Several models have been proposed for the evolution of Alzheimer's disease
(AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers …
(AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers …
Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss
Neuronal aging increases the risk of late-onset Alzheimer's disease. During normal aging,
synapses decline, and β-amyloid (Aβ) accumulates intraneuronally. However, little is known …
synapses decline, and β-amyloid (Aβ) accumulates intraneuronally. However, little is known …