Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Brain aging is closely related to neurodegenerative diseases. Circular RNAs (circRNAs) are
a type of conserved RNAs with covalently closed continuous loops. Emerging evidence has …

Aging brains undergo cognitive decline, associated with decreased neuronal synapse
number and function and altered metabolism. Astrocytes regulate neuronal synapse …

N6-methyladenosine (m6A) regulates mRNA metabolism. While it has been implicated in
the development of the mammalian brain and in cognition, the role of m6A in synaptic …

Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …

Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and
forms an important barrier between the central nervous system and the blood. For unknown …

Background It has been suggested that physical inactivity and lack of stimulating cognitive
activity are the two most significant modifiable risk factors to impair cognitive function …

Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …

Objective: Several models have been proposed for the evolution of Alzheimer's disease
(AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers …

Neuronal aging increases the risk of late-onset Alzheimer's disease. During normal aging,
synapses decline, and β-amyloid (Aβ) accumulates intraneuronally. However, little is known …