Introduction: Protein-protein interactions are important for biological processes and
pathological situations, and are attractive targets for drug discovery. However, rational drug …

We review various mathematical and computational techniques for drug discovery
exemplifying some recent works pertinent to group theory of nested structures of relevance …

Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including
Parkinson's disease. Amyloid formation of αSyn can be modulated by the 'P1 …

Obesity and type 2 and diabetes mellitus (T2D) are two dual epidemics whose shared
genetic pathological mechanisms are still far from being fully understood. Therefore, this …

The protein-ligand interactions play critical roles in targeted therapies including viral and
cancer therapies. Hence in recent years several experimental and computational methods …

Background: Protein-protein interactions (PPIs) are becoming increasingly important as PPIs
form the basis of multiple aggregation-related diseases such as cancer, Creutzfeldt-Jakob …

Hub proteins are important elements of interactomes within an organism; they bind diverse
partners, display significant pleiotropy, and connect many cellular systems. Static hubs …

Background Systematic analysis of a parasite interactome is a key approach to understand
different biological processes. It makes possible to elucidate disease mechanisms, to predict …

Stoichiometric balance, or dosage balance, implies that proteins that are subunits of obligate
complexes (eg the ribosome) should have copy numbers expressed to match their …

With the advancement of “proteomics” data and systems biology, new techniques are
needed to meet the new era of drug discovery. Network theory is increasingly applied to …