Regulatory T cells (Tregs) control inflammation and maintain immune homeostasis. The well-
characterised circulatory population of CD4+ Foxp3+ Tregs is effective at preventing …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Siponimod is a selective sphingosine 1-phosphate receptor subtype 1 (S1P1) and 5 (S1P5)
modulator approved in the United States and the European Union as an oral treatment for …

Background and Objectives There has been growing interest in potential roles of the
immune system in the pathogenesis of Parkinson disease (PD). The aim of the current study …

Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …

Background and Objectives Inflammasomes are involved in the pathogenesis of different
neuroimmune and neurodegenerative diseases, including multiple sclerosis (MS). In a …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which
leads, in many cases, to irreversible disability. More than 15 disease-modifying treatments …

Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested
the hypothesis that fingolimod modulates T‐cell cytokine production towards a regulatory …

Abstract Sphingosine 1-phosphate (S1P) is a potent bioactive sphingolipid binding to
specific G protein-coupled receptors expressed in several organs. The relevance of S1P …