Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to
synthesize anilines and aniline derivatives, an important class of compounds throughout …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological
characteristics have traditionally been considered to be homogeneous. In this study, we …

Background—Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)–
promoting remodeling. Here, we investigated fibroblast regulation by Ca2+-permeable …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Oxygen (O2) is a prerequisite for cellular respiration in aerobic organisms but also elicits
toxicity. To understand how animals cope with the ambivalent physiological nature of O2, it …