Club cell secretory protein in lung disease: emerging concepts and potential therapeutics

T Martinu, JL Todd, AE Gelman, S Guerra… - Annual review of …, 2023 - annualreviews.org
Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name
SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club …

Uteroglobin: A Steroid-Inducible Immunomodulatory Protein That Founded the Secretoglobin Superfamily

AB Mukherjee, Z Zhang, BS Chilton - Endocrine reviews, 2007 - academic.oup.com
Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted
protein that has been extensively studied from the standpoint of its structure and molecular …

A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects

JS Lakind, ST Holgate, DR Ownby, AH Mansur… - Biomarkers, 2007 - Taylor & Francis
Biomarkers associated with asthma aetiology and exacerbation have been sought to shed
light on this multifactorial disease. One candidate is the serum concentration of the Clara cell …

The club cell marker SCGB1A1 downstream of FOXA2 is reduced in asthma

L Zhu, L An, D Ran, R Lizarraga, C Bondy… - American journal of …, 2019 - atsjournals.org
Human SCGB1A1 protein has been shown to be significantly reduced in BAL, sputum, and
serum from humans with asthma as compared with healthy individuals. However, the …

Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic …

S Lock-Johansson, J Vestbo, GL Sorensen - Respiratory research, 2014 - Springer
Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be
fully described by the severity of airway obstruction. The limitations of spirometry and clinical …

[HTML][HTML] Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled …

E Tufvesson, H Svensson, J Ankerst, L Bjermer - Respiratory medicine, 2013 - Elsevier
Exercise is known to affect the airway epithelium through dehydration, followed by a release
of mediators, such as club cell (Clara) protein (CC16). The aim of this study was to follow the …

[HTML][HTML] Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers

K Romberg, L Bjermer, E Tufvesson - Respiratory medicine, 2011 - Elsevier
Elite swimmers have an increased risk of developing asthma, and exposure to chloramine is
believed to be an important trigger factor. The aim of the present study was to explore …

Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy

G Zhang, SK Khoo, T Laatikainen, P Pekkarinen… - Allergy, 2009 - Wiley Online Library
Background: Finnish Karelians have a higher prevalence of allergic disease than Russian
Karelians. As both populations are generally from the same ethnic group, the Karelian …

Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen‐challenged patients with intermittent allergic rhinitis

M Benson, M Fransson, T Martinsson, ÅT Naluai… - Allergy, 2007 - Wiley Online Library
Background: Decreased levels of the anti‐inflammatory Clara Cell Protein 16 (CC16) are
found in intermittent allergic rhinitis (IAR) and asthma. In asthma this decrease has been …

Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis

C De Burbure, P Pignatti, M Corradi, M Malerba… - Chest, 2007 - Elsevier
Abstract Rationale: Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16),
members of the secretoglobin family, increasingly appear to play a role in airway …