The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Injuries of the central (CNS) and peripheral nervous system (PNS) are a serious problem of
the modern healthcare system. The situation is complicated by the lack of clinically effective …

With sweeping advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Background Oxidative stress is a significant feature in the pathomechanism of
neurodegenerative diseases. Thus, the search for an effective and safe novel antioxidant …

Background Mechanisms of neuropathic pain are not fully understood. Molecular changes in
spinal dorsal horn take part in the initiation and development of neuropathic pain. Methods …

Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels,
is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy, and …

Parkinson's disease (PD) often manifests with prodromal pain and sensory losses whose
etiologies are not well understood. Multiple genetic and toxicity-based rodent models of PD …

Perioperative sleep disturbance is a risk factor for persistent pain after surgery. Clinical
studies have shown that patients with insufficient sleep before and after surgery experience …

Highlights•α2δ calcium channel subunits regulate channel trafficking and
conductance.•Glial/neuronal interactions utilize α2δ signaling for synapse …